Giant Benign Ovarian Serous Cystadenoma in a Postmenopausal Woman

Giant benign serous cystadenomas are ovarian tumors predominantly found in postmenopausal women, often presenting with nonspecific symptoms prior to diagnosis. This case study discusses an 80-year-old postmenopausal woman who experienced dyspnea and lower abdominal pain, leading to a contrast-enhanced abdominal computed tomography that revealed a well-defined giant cystic mass. The patient underwent a total hysterectomy with bilateral salpingo-oophorectomy (THBSO), with the excised specimen measuring 40 cm in diameter and weighing approximately 7.7 kg. Histopathological examination confirmed that cyst formation was lined by a single layer of columnar and cuboidal epithelium with fibrous stroma, identifying it as a benign serous cystadenoma. The patient had an uneventful postoperative recovery over 60 days. The uniqueness of this case lies in the patient's age and the atypical clinical presentation of the giant cystic mass. Additional clinical multicenter studies and molecular studies are needed to be done in the future in order to better understand the mechanism creating these tumors and tumorigenesis.