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Seeding the Spine: Salmonella Java Discitis and Osteomyelitis After Traveller's Bacteraemia
Nazar Abdelgabar1, Yahia Khalil2, Layan Abu-Khalaf3
1Gastroenterology and Hepatology, St Mary's Hospital, Isle of Wight NHS Trust, Newport, GBR.
Abstract:
Non-typhoidal Salmonella infection usually causes self-limiting gastroenteritis, but a minority of cases are complicated by bacteraemia and extraintestinal focal infection. Vertebral discitis and osteomyelitis are rare complications, most often described in patients with diabetes, haemoglobinopathy, or immunosuppression. We describe a 67-year-old man with hypertension and previous percutaneous coronary intervention who attended the emergency department five times over six weeks with fever, rigors, diarrhoea, and worsening thoracic back pain after travel to Sri Lanka and the Maldives. Blood cultures grew Salmonella Java susceptible to ceftriaxone, ciprofloxacin, and co-trimoxazole. Initial CT of the chest, abdomen, and pelvis was unremarkable. CT angiography performed several weeks later showed mid-thoracic vertebral destruction and disc space change. MRI confirmed severe T6-T7 discitis and osteomyelitis with prevertebral soft tissue involvement of the adjacent oesophagus and azygous vein, together with periaortic enhancement from T5/T6 to T9. CT angiography found no aortitis. A repeat echocardiogram showed no evidence of infective endocarditis. Treatment required several antimicrobial adjustments, including prolonged intravenous ceftriaxone and later oral step-down to amoxicillin. Back pain improved substantially and serial radiographs showed no vertebral collapse. This case illustrates that Salmonella Java can seed the spine without classical immunocompromising risk factors and that the diagnosis is often delayed when persistent back pain is initially attributed to travel-associated gastroenteritis. Recurrent or unresolved symptoms after a confirmed Salmonella bacteraemia warrant early spinal MRI.
Insights
Non-typhoidal Salmonella Java can cause rare spinal infections like discitis and osteomyelitis, even without typical risk factors. Prompt spinal MRI is crucial for diagnosing persistent symptoms after Salmonella bacteraemia.
Area of Science:
- Infectious Diseases
- Medical Case Reports
- Spinal Infections
Background:
- Non-typhoidal Salmonella typically causes gastroenteritis, but can lead to severe complications like bacteraemia and focal infections.
- Vertebral discitis and osteomyelitis are rare Salmonella complications, usually seen in immunocompromised individuals or those with specific comorbidities.
- This case highlights a patient with hypertension and prior coronary intervention who developed severe spinal infection.
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