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  1. Home
  3. In-situ Damascus-patterning Enables Tunable Surface Electric Fields For Bioactive Titanium Implants.
  1. Home
  3. In-situ Damascus-patterning Enables Tunable Surface Electric Fields For Bioactive Titanium Implants.

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In-situ Damascus-patterning enables tunable surface electric fields for bioactive titanium implants.

Hanyang Yu1,2, Nan Hou3, Subrahmanyam Pattamatta4

  • 1Department of Mechanical Engineering, City University of Hong Kong, Hong Kong, China.

Bioactive Materials
|June 15, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

New titanium-tantalum implants with Damascus-like patterns exhibit tunable surface potential differences, enhancing osseointegration and bone repair. This additive manufacturing approach integrates structural and biological functions for improved bioimplants.

Keywords:
Additive manufactureEndogenous electric fieldOsseointegrationSpontaneous polarizationStructure-function integration

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Area of Science:

  • Biomaterials Engineering
  • Orthopedic Implants
  • Surface Science

Background:

  • Conventional titanium implants are biocompatible but bioinert, necessitating surface modifications for effective osseointegration.
  • Achieving satisfactory osseointegration with current titanium implants often requires complex surface treatments.

Purpose of the Study:

  • To develop an additive manufacturing strategy for imparting bioactivity directly to titanium-tantalum implants.
  • To create implants with tunable periodic surface potential differences (P-SPD) for enhanced biological response.

Main Methods:

  • Utilized laser powder bed fusion to create titanium-tantalum implants with in situ compositional modulation.
  • Generated Damascus-like patterns through controlled tantalum melting into the titanium matrix.
  • Oxidized the patterned implants to produce stable, tunable P-SPD.

    • Main Results:

    • Achieved tunable P-SPD ranging from 5.59 to 48.01 mV, mimicking natural tissue electric fields.
    • The generated electric field (∼2.35 V/m) promoted osteogenesis, cell migration, and neural responses.
    • Demonstrated nearly doubled osteogenic performance in vitro and in vivo cranial defect repair compared to controls.

    Conclusions:

    • Additive manufacturing enables in situ integration of structural and biological functions in high-performance titanium-tantalum implants.
    • The P-SPD generated by Damascus-like patterns significantly enhances osseointegration and bone regeneration.
    • This approach offers a novel paradigm for bioimplant surface functionalization.