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Sacrocolpopexy Using Polyvinylidene Fluoride Mesh: A Systematic Review and Meta-Analysis
Mahdi Norouzi1,2, Mahtab Zargham3, Farshad Gholipour1,2
1Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, mui.ac.ir.
Advances in Urology
|June 15, 2026
Summary
Polyvinylidene fluoride (PVDF) mesh shows promising outcomes in sacrocolpopexy (SCP) with low complication rates. However, current evidence is limited, necessitating further research to confirm its efficacy compared to polypropylene (PP) mesh.
Area of Science:
- Urogynecology
- Pelvic Floor Surgery
- Biomaterials Science
Background:
- Sacrocolpopexy (SCP) is a surgical procedure to treat pelvic organ prolapse.
- The choice of mesh material can impact clinical outcomes and complication rates.
- Polyvinylidene fluoride (PVDF) mesh is a newer option for SCP.
Purpose of the Study:
- To systematically review and meta-analyze the clinical outcomes and complications associated with PVDF mesh in SCP.
- To compare the efficacy and safety of PVDF mesh against conventional materials, specifically polypropylene (PP) mesh.
Main Methods:
- A systematic search of major scientific databases (Google Scholar, PubMed, Web of Science, Scopus, Embase) was performed up to October 2024.
- Studies utilizing PVDF mesh in SCP, regardless of design, were included.
- Data on demographics, mesh type, surgical approach, outcomes, and complications were extracted and analyzed.
Main Results:
- Twelve studies involving 1093 patients were included in the meta-analysis.
- PVDF mesh demonstrated pooled prevalence rates near 0% for mesh exposure, recurrence, sexual dysfunction, and reoperation.
- Prevalence rates for urge urinary incontinence (UUI) were 33%, and for stress urinary incontinence (SUI) and de novo incontinence were 6%.
Conclusions:
- No statistically significant differences in outcomes or complications were observed between PVDF and PP mesh.
- While PVDF mesh shows favorable initial results, further high-quality evidence is required to establish definitive comparisons with conventional materials like PP.
