Related Experiment Video
Updated: Jun 16, 2026
04:37
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
Coagulation activation in anorexia nervosa: increased tissue factor and prothrombin fragment 1+2
Jeanie Meincke Egedal1,2,3,4, Else-Marie Bladbjerg5,6, Jan Magnus Sjögren7,8
1Center for Eating Disorders, Odense University Hospital, Odense, Denmark.
Research and Practice in Thrombosis and Haemostasis
|June 15, 2026
Summary
Patients with anorexia nervosa show mild blood clotting activation, with higher tissue factor and prothrombin fragment 1+2 levels. This suggests a shift toward in vivo coagulation, but not a procoagulant state.
Area of Science:
- Hematology
- Clinical Biochemistry
- Thrombosis Research
Background:
- Anorexia nervosa (AN) is linked to increased risk of venous and arterial thromboses.
- Coagulation system in AN patients remains incompletely understood.
Purpose of the Study:
- Investigate the coagulation profile in AN patients.
- Assess tissue factor (TF) and contact activation pathways in plasma and whole blood.
Main Methods:
- Cross-sectional case-control study with 40 AN patients and 40 controls.
- Analyzed plasma coagulation markers, thrombin and kallikrein generation, and thromboelastometry variables.
Main Results:
- AN patients had higher plasma TF, prothrombin fragment 1+2, C1 inhibitor, and high-molecular-weight kininogen.
- Reduced kallikrein generation was observed in AN patients.
- No significant differences in thrombin generation or thromboelastometry were found.
Conclusions:
- AN patients exhibit modest coagulation activation with elevated TF and prothrombin fragment 1+2.
- Increased C1 inhibitor and reduced contact activation potential noted.
- Findings suggest a shift toward in vivo coagulation activation in AN, warranting further research.
Related Concept Videos
01:20Extrinsic and Intrinsic Pathways of Hemostasis
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
01:09Coagulation
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
01:06Coagulation
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
01:28Anorexia Nervosa
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
01:16Clot Retraction and Fibrinolysis
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.