Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Two-Compartment Open Model: Extravascular Administration01:12

Two-Compartment Open Model: Extravascular Administration

The two-compartment model for extravascular administration represents a drug's absorption and distribution process. It features a central compartment, where the drug is first absorbed, and a peripheral compartment, which illustrates the drug's distribution throughout the body. The rate of change in drug concentration in the central compartment is calculated by three exponents: absorption, distribution, and elimination.
The absorption exponent (ka) indicates the speed at which the drug is...
One-Compartment Open Model: Urinary Excretion Data and Determination of k01:11

One-Compartment Open Model: Urinary Excretion Data and Determination of k

The one-compartment open model leverages urinary excretion data to estimate renal clearance, which gauges the kidney's capacity to expel a drug. This method offers several benefits, including directly measuring drug elimination and assessing the kidney's contribution to overall drug clearance. However, this approach has limitations. It assumes sole renal excretion of the drug, which is not true for all drugs. Accurate urinary excretion and plasma drug concentration measurement can also be...
Three-Compartment Open Model01:06

Three-Compartment Open Model

The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In reply: epidemiology of immune-mediated thrombotic thrombocytopenic purpura in Germany.

Research and practice in thrombosis and haemostasis·2026
Same author

APOSCREEN-1 - a prospective, single-arm clinical trial for the implementation of a pharmacy-based screening for cardiovascular-kidney-metabolic risk factors in Schleswig-Holstein.

BMC nephrology·2026
Same author

Qualified prediction system for allograft failure in real world settings: extended validation study.

BMJ medicine·2026
Same author

Clinical Relevance of Donor-Derived cfDNA In Monitoring Kidney Transplant Rejection.

Journal of the American Society of Nephrology : JASN·2026
Same author

Case-Control and Longitudinal Study of Sex Steroids in Male Patients with CKD Before and After Kidney Transplantation.

Kidney international reports·2026
Same author

Shall we go for a walk? A cross-sectional study comparing the 6 min walk test and cardiopulmonary exercise test for assessing cardiorespiratory fitness in de novo kidney transplant recipients.

BMJ open sport & exercise medicine·2026
Same journal

Delayed graft function and long-term outcomes after deceased donor kidney transplantation: insights from mate-kidney analysis.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Regulatory approach to manipulated organs in Europe: preserving human organs as non-commercial goods.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Can european law keep pace with biomedical innovation? The reinvention of transplantation regulation.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Sex-related differences in survival based on [<sup>18</sup>F]FDG PET/CT metabolic tumor volume after liver transplantation for colorectal liver metastases.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Not all antibodies are created equal: total IgG glycosylation and severity of antibody-mediated rejection in kidney transplantation.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Elevated filling pressures are associated with poor long-term graft survival after pediatric heart transplantation.

Transplant international : official journal of the European Society for Organ Transplantation·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

A discrete time simulation model for kidney allocation in Germany.

Nassim Kakavand1, Maarten Coemans2, Hans C de Ferrante3,4

  • 1Department of Anesthesiology and Intensive Care Medicine, University Medical Center Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany.

Transplant International : Official Journal of the European Society for Organ Transplantation
|June 15, 2026
PubMed
Summary
This summary is machine-generated.

A new simulation model optimizes kidney allocation by evaluating policy changes. It showed that removing the European Senior Program improved transplant rates for younger adults but worsened access for older patients.

Keywords:
EurotransplantGermanydiscrete time simulationkidney allocationsimulated allocation models

More Related Videos

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry
07:58

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry

Published on: August 21, 2020

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Related Experiment Videos

Last Updated: Jun 16, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry
07:58

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry

Published on: August 21, 2020

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Area of Science:

  • Nephrology
  • Transplantation
  • Health Services Research

Background:

  • Kidney donation shortages necessitate optimized organ allocation strategies.
  • Simulation models offer a method to evaluate policy impacts before implementation.
  • Current kidney allocation systems face challenges in balancing utility and equity.

Purpose of the Study:

  • To develop and validate a discrete time simulation model for the German kidney allocation process.
  • To assess the impact of policy changes on kidney allocation outcomes.
  • To explore the effects of omitting the European Senior Program (ESP) on kidney transplantation.

Main Methods:

  • Utilized data from the German national transplant registry, bone marrow donor registry (HLA information), and Eurotransplant database.
  • Developed a discrete time simulation model to reconstruct the German kidney allocation process.
  • Validated the model by simulating 2006-2017 and comparing outputs with historical data.

Main Results:

  • The simulation model demonstrated high accuracy in replicating historical kidney allocation data (waiting list size, transplants, age, HLA mismatch, survival).
  • Omitting the European Senior Program (ESP) reduced waiting times for younger adults and slightly improved overall transplant survival.
  • Excluding the ESP negatively impacted transplantation access for older patients.

Conclusions:

  • The developed discrete time simulation model serves as a valuable tool for assessing kidney allocation policy trade-offs.
  • Policy modifications can impact different patient demographics unequally, highlighting the need for careful consideration.
  • Further research is needed to extend the model's applicability to the broader Eurotransplant region.