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Nitrosoarenes as Versatile Precursors for 18F‑Fluorination
Markus Laube1, Silvia Roscales2, Jens Pietzsch1,3
1Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden 01328, Germany.
None:
Fluorine-18 is a central radionuclide for positron-emission tomography. The [18F]-fluoro-for-nitroso exchange has not yet been utilized for radiofluorination. Herein, we report the first insights into this transformation and its substrate scope based on the evaluation of 25 model compounds. Since nitrosoarenes are readily obtained from anilines or nitroarenes, this approach creates a direct link between these common functional groups and 18F labeling and now allows versatile access to labeling precursors from aromatic amines.
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