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A life course approach to preventing chronic kidney disease by limiting long-term consequences of early adverse

Lieke A Hoogenboom1,2, Jeremy Hughes3, Victoria A Ilori4

  • 1Bristol Royal Hospital for Children - Bristol and Weston NHS Foundation Trust, Bristol, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|June 15, 2026
PubMed

Insights

Preventing chronic kidney disease (CKD) may be possible by understanding early life genetic and environmental factors. Monitoring kidney health in youth using novel biomarkers could improve prognosis and guide new treatment development.

Area of Science:

  • Nephrology
  • Developmental Biology
  • Preventive Medicine

Background:

  • Chronic kidney disease (CKD) is a growing global health issue.
  • Current treatments for CKD focus on managing established kidney damage and failure.
  • A preventative approach targeting early life kidney development is needed.

Purpose of the Study:

  • To explore the impact of early life "hits" on kidney development and long-term CKD risk.
  • To investigate the potential of novel urine biomarkers for assessing kidney health in young individuals.
  • To identify research pathways for developing new CKD prevention and treatment strategies.

Main Methods:

  • Review of existing literature on prenatal and early postnatal kidney development.
  • Discussion of genetic and environmental factors influencing kidney maturation.
  • Exploration of emerging urine biomarkers for nephron number and kidney cell senescence.

Main Results:

  • Early adverse events during development can significantly impact future kidney health.
  • Urine biomarkers may offer insights into kidney prognosis and identify individuals for clinical trials.
  • Understanding early "hits" can inform strategies for CKD prevention.

Conclusions:

  • A shift towards early detection and prevention of CKD is crucial.
  • Novel biomarkers hold promise for personalized kidney health management.
  • Further translational research is needed to develop and validate new interventions.
Keywords:
biomarkerenvironmentgeneticsneonatenephrogenesissenescence

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