Related Experiment Video
Updated: Jun 16, 2026
Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
Toward a definition of a core outcome set in neuromyelitis optica spectrum disorder: a scoping review protocol
Cristian E Navarro1, María Isabel Zuluaga2, Sarah L Gorst3
1School of Medicine, Universidad de Antioquia, Medellín, Colombia.
Objective:
This scoping review will examine the available evidence to identify the main outcomes, their definitions, and how they were measured, along with the values, preferences, and experiences, of adult patients with aquaporin-4 immunoglobulin G antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorder (NMOSD).
Introduction:
NMOSD encompasses a group of inflammatory central nervous system disorders that cause optic neuritis and myelitis. Therapies have different mechanisms of action, but their efficacy has not been fully compared due to variability of outcomes used in randomized controlled trials. No attention has been paid to the selection of outcomes, and primary and secondary outcomes commonly depend on the researcher's preferences. This issue could be addressed through core outcome sets (COS) which establish the key outcomes that should be assessed in randomized controlled trials. Such COS are currently lacking, and this review will provide a better understanding of COS for NMOSD to facilitate their further development and standardization.
Eligibility Criteria:
The review will consider qualitative and quantitative primary studies, conducted in any clinical context, reporting on adult patients with AQP4-IgG-seropositive NMOSD; exploring outcomes, their definitions, and how they were measured; and examining the values, preferences, and experiences of patients.
Methods:
The review will follow the JBI methodology for scoping reviews. Databases to be searched will include Cochrane CENTRAL (Ovid), MEDLINE (Ovid), Embase (Ovid), and PsycINFO (EBSCOhost); gray literature (medRxiv) will also be searched. Three reviewers will independently screen titles and abstracts, and then full texts. Data will be extracted using a customized tool. Outcomes will be classified using a taxonomy system. A narrative summary will accompany the tabulated and charted results.
Review Registration:
COMET https://www.comet-initiative.org/Studies/Details/3440).
Protocol Registration:
OSF https://osf.io/knrhc/.
Related Concept Videos
01:20Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
01:19Multiple Sclerosis l: Introduction
01:11Clinical Trials: Overview
01:11Guidelines for Writing Outcome
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care evaluation by...
01:19Standards of Care II
01:15Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...