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Published on: March 15, 2024

[Cefoperazone/sulbactam-induced coagulopathy following pancreatic surgery]

A A Karpov1,2, M M Tavobilov1,2, D A Eremin1

  • 1Botkin Hospital, Moscow, Russia.

Khirurgiia
|June 15, 2026
PubMed

Insights

Cefoperazone/sulbactam, a common antibiotic, is linked to serious bleeding risks due to coagulopathy. This study highlights the need for vigilance regarding this adverse event, especially in postoperative patients.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Infectious Diseases

Background:

  • Cefoperazone/sulbactam is frequently used for infections caused by beta-lactamase-producing organisms.
  • Adverse event reports indicate safety concerns, with coagulopathy being a significant complication.
  • Previous studies suggest an increased bleeding risk associated with this antibiotic.

Purpose of the Study:

  • To investigate cefoperazone/sulbactam-induced coagulopathy in Russian patients.
  • To document coagulation disorders following pancreatic resections linked to this antibiotic.
  • To address the lack of Russian data on this specific adverse effect.

Main Methods:

  • Retrospective analysis of patients undergoing pancreatic resections.
  • Monitoring of coagulation parameters in the early postoperative period.
  • Association of cefoperazone/sulbactam administration with observed coagulation disorders.

Main Results:

  • Patients developed significant coagulation disorders post-pancreatic resection.
  • Cefoperazone/sulbactam administration was associated with these bleeding complications.
  • The findings align with international reports on cefoperazone/sulbactam-induced coagulopathy.

Conclusions:

  • Cefoperazone/sulbactam poses a substantial risk of coagulopathy and bleeding, particularly in postoperative settings.
  • Clinicians should be aware of this potential adverse effect when prescribing this antibiotic.
  • Further research is needed to elucidate the mechanisms and management of this complication.
Keywords:
cefoperazone/sulbactamdrug-induced coagulopathypancreatic surgerypostoperative bleeding

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