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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
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Published on: April 3, 2026

Can markers predict plaque vulnerability?

Dianne Acoba1, Isabel Gonçalves2

  • 1Cardiovascular Research Translational Studies, Clinical Sciences Malmö, Lund University, Malmö, Sweden.

Atherosclerosis
|June 15, 2026
PubMed
Summary
This summary is machine-generated.

Identifying vulnerable plaques (VP) and patients is crucial for preventing cardiovascular events. This review explores plaque vulnerability markers, highlighting unmet needs in early detection and risk stratification for targeted therapies.

Keywords:
AtherosclerosisBiomarkersImagingPlaque vulnerabilityVulnerable patientVulnerable plaque

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Last Updated: Jun 17, 2026

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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

Area of Science:

  • Cardiovascular Research
  • Atherosclerosis Pathophysiology
  • Biomarker Discovery

Background:

  • The concept of vulnerable plaque (VP) has evolved beyond thin-cap fibroatheroma to include diverse atherosclerotic lesions.
  • Identifying the "vulnerable patient" is increasingly recognized as critical for predicting cardiovascular and cerebrovascular events.
  • Traditional risk factors have limited predictive power for clinical complications, indicating a need for novel markers.

Purpose of the Study:

  • To review local and systemic plaque vulnerability markers for early detection of high-risk patients.
  • To summarize research and clinically used markers, including circulating and imaging modalities.
  • To identify gaps in marker discovery, development, and implementation and envision future directions.

Main Methods:

  • Comprehensive literature review of plaque vulnerability markers.
  • Analysis of circulating, local, and imaging-based markers (invasive and noninvasive).
  • Discussion of current research and clinical applications of identified markers.

Main Results:

  • A wide array of plaque vulnerability markers exist, spanning research and clinical use.
  • Both circulating and imaging markers show potential for risk stratification.
  • Significant gaps remain in the discovery, development, and clinical implementation of these markers.

Conclusions:

  • Early identification of vulnerable plaques and patients is essential for effective cardiovascular event prevention.
  • Novel plaque vulnerability markers are needed to improve risk stratification beyond traditional factors.
  • Future research should focus on bridging the gap between marker discovery and clinical application for personalized patient care.