Exploring TRPM7 Channel-Kinase for Disease Modulation: A Translational Approach

Area of Science:

• Biomedical Science
• Molecular Biology
• Pathophysiology

Background:

• The transient receptor potential melastatin-7 (TRPM7) channel-kinase plays a significant role in human diseases.
• Its integrated ion channel and kinase functions are implicated in oncological, neurological, cardiovascular, and immunological disorders.

Purpose of the Study:

• To review the involvement of TRPM7 in human disease.
• To evaluate TRPM7 as a selective therapeutic target.
• To emphasize TRPM7's contribution to pathogenic mechanisms.

Main Methods:

• A literature survey from 2010-2025 was conducted using major biomedical databases.
• Evidence from molecular, cellular, experimental, and clinical studies was synthesized.
• Focused on TRPM7's regulation of cell proliferation, migration, apoptosis, and immune signaling.

Main Results:

• TRPM7 regulates intracellular Mg2+ and Ca2+ homeostasis, influencing multiple signaling pathways.
• Aberrant TRPM7 expression/activity is linked to malignancy, neurodegeneration, cardiovascular dysfunction, and autoimmune disease.
• Pharmacological TRPM7 modulation showed benefits in preclinical models.

Conclusions:

• TRPM7's unique channel-kinase structure controls ion flux and signaling, impacting inflammation, oxidative stress, and cellular remodeling.
• Context-dependent roles suggest opportunities for selective TRPM7 intervention.
• TRPM7 is a key disease mediator and a promising therapeutic target.