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Related Experiment Videos

Association Between Systemic Inflammation Indices and Recurrence Risk in Primary Budd-Chiari Syndrome.

Ziyuan Shen1, Man Ni1, Yang Liu1

  • 1Clinical Research Institute, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, People's Republic of China.

Journal of Inflammation Research
|June 16, 2026
PubMed
Summary

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This summary is machine-generated.

Inflammation markers like elevated neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) predict Budd-Chiari syndrome (BCS) recurrence. Higher lymphocyte-to-monocyte ratio (LMR) offers protection, aiding in patient surveillance.

Area of Science:

  • Hepatology
  • Thrombotic liver disorders
  • Inflammatory markers

Background:

  • Budd-Chiari syndrome (BCS) is a rare liver disorder characterized by hepatic venous outflow obstruction.
  • BCS carries a high risk of recurrence despite treatment.
  • The predictive value of inflammation-based markers for BCS recurrence is not well-established.

Purpose of the Study:

  • To investigate the association between systemic inflammation indices and the risk of recurrence in primary Budd-Chiari syndrome.
  • To identify specific inflammatory markers that can predict post-treatment recurrence in BCS patients.

Main Methods:

  • Retrospective cohort study of 708 primary BCS patients (2015-2022).
  • Calculation of nine systemic inflammatory indices from baseline parameters.
Keywords:
Budd-Chiari syndromeinflammatory indicesrecurrenceweighted quantile sum

Related Experiment Videos

  • Logistic regression and weighted quantile sum (WQS) regression used to evaluate associations with recurrence.

    • Main Results:

    • 31.9% of patients experienced recurrence during follow-up.
    • Elevated neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were linked to increased recurrence risk.
    • Higher lymphocyte-to-monocyte ratio (LMR) showed a protective effect; neutrophil-to-albumin ratio (NAR) and monocyte-to-albumin ratio (MAR) emerged as key predictors.

    Conclusions:

    • Systemic inflammation markers are independently associated with recurrence risk in primary BCS.
    • These inflammatory indices may serve as valuable tools for monitoring BCS recurrence.
    • Findings were consistent across subgroups, particularly in IVC-type BCS and cirrhotic patients.