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Updated: Jun 17, 2026
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An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
Published on: May 4, 2021
Comment on: miR-129-5p Modulates Fndc5 Expression in Adipose Tissue of Diabetic Mice
Baharuddin Baharuddin1, Lilies Handayani2, Maher Monir Akl3
1Faculty of Medicine, University of Surabaya, Kalirungkut, Surabaya, Indonesia.
Cell Journal
|June 16, 2026
Summary
Increased miR-129-5p expression correlates with lower Fndc5 levels in a mouse model of type 2 diabetes mellitus (T2DM). Further research is needed to confirm causality and explore metabolic implications.
Area of Science:
- Biochemistry
- Molecular Biology
- Endocrinology
Background:
- Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder characterized by insulin resistance.
- Fibronectin Type III Domain Containing 5 (FNDC5) and its cleavage product, irisin, play roles in metabolic regulation.
- MicroRNAs (miRNAs) are emerging as key regulators of gene expression in metabolic diseases.
