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Updated: Jun 17, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Spiro-[indene-1,2'-indolin] scaffolds via Rh(III) catalyzed C-H activation/[3+2] spiroannulation

Imtiaj Mondal1, Gracy Salam1, Sudip Karmakar1

  • 1Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4-Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India. imtiaj612@gmail.com.

Chemical Communications (Cambridge, England)
|June 16, 2026
PubMed
Summary

Researchers developed a new Rh(III) catalyzed reaction for synthesizing complex spirocyclic compounds from indole derivatives and alkynes. This method efficiently creates valuable C2-spiro-[indene-1,2′-indolin] scaffolds with potential biological applications.

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