Related Experiment Video
Updated: Jun 17, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
Redefining Radiotherapy: The Gut as an Active Target in Immuno-oncology
Eric Deutsch1, Antonin Levy1, Laurence Zitvogel2
1Université Paris-Saclay, Institut Gustave Roussy, Inserm U1355, Molecular Radiotherapy and Therapeutic Innovations, Villejuif, France.
None:
Low-dose intestinal irradiation challenges the long-standing view of the gut as a radiation-sensitive organ to avoid. Clinical and mechanistic data suggest that targeted exposure of the small intestine within a 1- to 3-Gy window can remodel the microbiome and enhance systemic antitumor immunity. See related article by Huang et al., p. 3586.
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