Clinical outcomes of patients bilaterally implanted with the light adjustable lens: results of a phase IV clinical...

To report the outcomes of the light adjustable lens (LAL) collected from a clinical registry.

Multiple private practices in the United States.

Multicenter prospective observational study.

Patients who underwent bilateral LAL implantation and who had corrected distance visual acuity ≥20/20 -2 before lens adjustment were enrolled. Assessment was performed at one visit 1 to 3 months after final lock-in treatment.

A total of 1101 participants (2202 eyes) were included. Of these, 586 eyes had prior corneal refractive surgery (CRS) and 1616 had no prior CRS (No CRS). 12.3% of participants were targeted for bilateral emmetropia, 9.3% for bilateral near, and 78.4% for blended vision. Of eyes targeted for emmetropia, 81.2% achieved a uncorrected distance visual acuity (UDVA) of ≥20/20 (82.2% of No CRS and 78.4% of CRS). A total of 94.3% of eyes targeted for emmetropia had a manifest spherical equivalent (MSE) of ≤0.5 diopter (D) (94.7% of No CRS, 92.8% of CRS). The mean prediction error in MSE was -0.048 ± 0.366 D in No CRS and -0.016 ± 0.441 D in CRS. A total of 89% of patients with blended vision and 93% of patients with bilateral emmetropic target had binocular UDVA of ≥20/20. In the CRS group, 87% with blended vision and 87% with binocular emmetropia achieved binocular UDVA of ≥20/20. Binocular uncorrected near visual acuity of ≥J1 was achieved with blended vision in 85% of patients in the No CRS group and 82% of patients in the CRS group.

In this multicenter study, patients achieved a high degree of precision with the LAL regardless of prior CRS.