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Related Experiment Video

Updated: Jul 3, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

Exploring causality between peripheral blood B cell subtypes and membranous nephropathy: a two-sample Mendelian

Zhiyong Zhang1, Jun Zhao1, Ting Yan1

  • 1Department of Nephrology, The Sixth Medical Center of PLA General Hospital, Beijing, China.

Archives of Medical Science : AMS
|June 17, 2026
PubMed
Summary

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This study used Mendelian randomization to investigate how peripheral blood B cell subtypes influence membranous nephropathy (MN). Certain B cell subtypes and markers are genetically linked to a reduced risk of developing this autoimmune kidney disease.

Area of Science:

  • Immunology
  • Nephrology
  • Genetics

Background:

  • Membranous nephropathy (MN) is an autoimmune glomerular disease causing nephrotic syndrome.
  • Understanding the role of peripheral blood B cell subtypes in MN pathogenesis is crucial.

Purpose of the Study:

  • To explore the potential causal influence of peripheral blood B cell subtypes on the risk of developing membranous nephropathy (MN).
  • To utilize Mendelian randomization (MR) to investigate genetic associations between B cell subtypes and MN.

Main Methods:

  • Mendelian randomization (MR) analysis using genome-wide association study (GWAS) data for single-nucleotide polymorphisms (SNPs) related to peripheral blood B cells and MN.
  • Employed instrumental variable weighted (IVW), weighted median, weighted mode, and MR-Egger regression methods.
Keywords:
B cellMendelian randomizationgenome-wide association studymembranous nephropathy

Related Experiment Videos

Last Updated: Jul 3, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

  • Conducted sensitivity analyses including MR-Egger, MR-PRESSO, Cochran's Q test, and leave-one-out analysis to ensure result robustness.

    • Main Results:

    • Several peripheral blood B cell subtypes and their marker expressions were significantly associated with a decreased risk of MN.
    • Key findings include associations for IgD+ CD24-B cell absolute count, B-cell activating factor receptor (BAFF-R) on various B cell subsets (IgD+ CD24-, IgD+ CD38dim, IgD- CD27-), CD19 on IgD-CD24-B cells, CD24 on switched memory B cells, and CD25 on switched memory B cells.
    • Sensitivity analyses confirmed the stability and reliability of these genetic associations.

    Conclusions:

    • This MR study provides evidence for a potential genetic causal relationship between specific peripheral blood B cell subtypes and membranous nephropathy.
    • The findings enhance the understanding of the immunological underpinnings of MN.
    • These insights may contribute to the future development of personalized medicine approaches for MN.