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Updated: Jun 18, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
A Comparison Between Two Different Directions of Landmark-Guided Femoral Vein Puncture: A Prospective Randomized
Feng Liu1, Xin Wang2, Zhaoming Guan1
1Department of Anesthesiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China, tongji.edu.cn.
The lateral approach for femoral vein puncture significantly improves first-attempt success rates and reduces procedure time compared to the orthogonal approach. This method enhances safety and efficiency in percutaneous procedures without increasing complications.
Area of Science:
- Vascular Access Techniques
- Interventional Cardiology
- Anatomy and Physiology
Background:
- Anatomical variations between the femoral vein and artery increase the risk of vascular injury during percutaneous procedures.
- Clinical evidence comparing different femoral vein puncture directions is limited.
- Understanding optimal puncture techniques is crucial for patient safety.
Purpose of the Study:
- To prospectively compare the efficacy and safety of lateral versus orthogonal femoral vein puncture approaches.
- To evaluate the impact of puncture direction on success rates, procedure time, and complications.
- To identify specific anatomical scenarios where one approach may be superior.
Main Methods:
- A prospective randomized controlled trial was conducted with 108 patients undergoing percutaneous femoral venous catheterization.
- Patients were randomized into two groups: lateral puncture approach and orthogonal puncture approach.
- Primary outcome was first-attempt success rate; secondary outcomes included overall success, attempts, time, and complications.
Main Results:
- The lateral approach group showed a significantly higher first-attempt success rate (76% vs. 52%) and overall success rate (91% vs. 61%).
- Fewer puncture attempts (p=0.004) and shorter puncture times (median difference: -6.0s) were observed with the lateral approach.
- The benefits of the lateral approach were more pronounced when femoral artery and vein lumen overlap occurred; complication rates were similar between groups.
Conclusions:
- The lateral approach for femoral vein puncture, using anatomical landmarks, enhances success rates and reduces operating time.
- This technique is particularly advantageous in cases with partial or complete femoral artery and vein overlap.
- The lateral approach does not increase the risk of local complications, making it a safer and more efficient option.
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