Rhabdomyolysis-Induced Resistant Hypercalcemia During the Recovery Phase of Acute Kidney Injury

Rhabdomyolysis is a clinical syndrome characterized by skeletal muscle injury and the release of intracellular contents into the circulation. While early hypocalcemia is common, hypercalcemia during the recovery phase is a rare but serious complication. We present a case of a 36-year-old male who developed severe, refractory hypercalcemia following rhabdomyolysis-induced acute kidney injury. Despite standard treatment with loop diuretics, low-calcium hemodialysis, and calcitonin, the hypercalcemia persisted. In this report, we highlighted a rebound hypercalcemia occurring during recovery from rhabdomyolysis, a biphasic disturbance in calcium homeostasis, and emphasized the importance of careful monitoring and timely, judicious management.