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Nodular Granulomatous Phlebitis: A Case Report and Literature Review
Noé Duperrier-Ruiz1, Rosario Haro-Ramos1, Carolina Areán-Cuns2
1Dermatology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain; and.
The American Journal of Dermatopathology
|June 17, 2026
Summary
Nodular granulomatous phlebitis, a rare tuberculid, presents as vein inflammation mimicking other skin conditions. Accurate diagnosis via histopathology is crucial to avoid incorrect treatment and potential tuberculosis reactivation.
Area of Science:
- Dermatology
- Pathology
- Infectious Diseases
Background:
- Nodular granulomatous phlebitis is a rare, underdiagnosed tuberculid.
- It involves granulomatous inflammation of subcutaneous veins.
- Clinically, it can be mistaken for panniculitis or superficial thrombophlebitis.
Purpose of the Study:
- To report a new case of nodular granulomatous phlebitis.
- To review the literature comprehensively.
- To delineate the clinical and histopathologic spectrum of this entity.
Main Methods:
- Case report.
- Comprehensive literature review.
- Histopathologic examination.
Main Results:
- Histopathologic findings are essential for diagnosis.
- This condition is often poorly recognized.
- Failure to diagnose may lead to inappropriate immunosuppressive therapy.
Conclusions:
- Nodular granulomatous phlebitis is a distinct tuberculid requiring histopathologic confirmation.
- Dermatologists and pathologists must be aware of this entity.
- Timely diagnosis prevents risks associated with incorrect treatment, including tuberculosis reactivation.
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