Related Experiment Videos
Nodular Granulomatous Phlebitis: A Case Report and Literature Review
Noé Duperrier-Ruiz1, Rosario Haro-Ramos1, Carolina Areán-Cuns2
1Dermatology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain; and.
The American Journal of Dermatopathology
|June 17, 2026
Summary
Nodular granulomatous phlebitis, a rare tuberculid, presents as vein inflammation mimicking other skin conditions. Accurate diagnosis through histopathology is crucial to avoid incorrect treatments and potential tuberculosis reactivation.
Area of Science:
- Dermatology
- Pathology
- Infectious Diseases
Background:
- Nodular granulomatous phlebitis is a rare, underdiagnosed tuberculid.
- It involves granulomatous inflammation of subcutaneous veins.
- Clinically, it can be mistaken for panniculitis or superficial thrombophlebitis.
Purpose of the Study:
- To report a new case of nodular granulomatous phlebitis.
- To comprehensively review the literature on this entity.
- To delineate the clinical and histopathologic spectrum of nodular granulomatous phlebitis.
Main Methods:
- Case report of nodular granulomatous phlebitis.
- Comprehensive literature review.
Main Results:
- Histopathologic findings are essential for diagnosis.
- Nodular granulomatous phlebitis is a poorly recognized tuberculid.
- The study aims to improve understanding of its clinical and histopathologic features.
Conclusions:
- Awareness of nodular granulomatous phlebitis is critical for dermatologists and pathologists.
- Misdiagnosis can lead to inappropriate immunosuppressive therapy.
- Failure to recognize this condition carries a risk of latent tuberculosis reactivation.
Related Concept Videos
01:23Chronic Pharyngitis
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
01:12Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...