Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iChip01:24

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell impedance sensing on integrated circuit chip for fast tumor diagnosis.

Microsystems & nanoengineering·2026
Same author

Programmable On-Chip Manipulation and Separation of Biological Cells Using a Rotating AC-FFET Platform.

Analytical chemistry·2026
Same author

Methods for Blood Separation and Detection in Laboratory, On-Site, and Home-Based Scenarios.

Analytical chemistry·2026
Same author

Wearable Electrical-impedance-tomography Armband for Noninvasive and Continuous Bone Monitoring.

ACS sensors·2025
Same author

Equivalent Circuit Modeling and Analysis for Microfluidic Electrical Impedance Monitoring of Single-Cell Growth.

Biosensors·2025
Same author

Microfluidic programmable strategies for channels and flow.

Lab on a chip·2024
Same journal

A Point-of-Care System for the Quantification of Small-Molecule Drugs in Blood.

ACS sensors·2026
Same journal

A Fungal Bioluminescent Pathway (FBP)-Based Yeast Biosensor for Caffeic Acid Quantification in Food and Beverages.

ACS sensors·2026
Same journal

Additively Manufactured <i>in planta</i> Integrated Microneedle-Microfluidic Sensing: Nondestructive Electrochemical Tracking of Glucose and Water Stress in Agricultural Crop Plants.

ACS sensors·2026
Same journal

Printable Core-Shell Multifunctional Particle for Light-Enhanced Nanomolar-Level Testosterone Point-of-Care Monitoring.

ACS sensors·2026
Same journal

Robust and Sensitive Electrochemical Biosensor Based on Cascade Interface Engineering for piRNA Detection in Breast Cancer Diagnosis.

ACS sensors·2026
Same journal

CRISPR-Cas-Based Platform for Single-Step Quantification of Monoclonal Antibodies at Point-of-Care.

ACS sensors·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

Quantitative High-throughput Single-cell Cytotoxicity Assay For T Cells
09:28

Quantitative High-throughput Single-cell Cytotoxicity Assay For T Cells

Published on: February 2, 2013

Cells on IC Chip.

Wenhao Hui1,2,3, Yanheng Wang1, Mingji Wei1

  • 1School of Electrical and Information Engineering, Jiangsu University, Zhenjiang 212013, PR China.

ACS Sensors
|June 17, 2026
PubMed
Summary
This summary is machine-generated.

Integrated circuit technology, combining CMOS and MEMS, revolutionizes cellular signal analysis for precision medicine. This chip-level approach enables high-resolution detection of multimodal cellular signals, advancing diagnostics and research.

Keywords:
CMOS−MEMScellular signalingchemical sensingelectrophysiology sensingintegrated circuits (ICs)lab-on-chipmechanical sensingmultimodal sensingoptical sensing

More Related Videos

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Related Experiment Videos

Last Updated: Jun 19, 2026

Quantitative High-throughput Single-cell Cytotoxicity Assay For T Cells
09:28

Quantitative High-throughput Single-cell Cytotoxicity Assay For T Cells

Published on: February 2, 2013

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Area of Science:

  • Biotechnology and Biomedical Engineering
  • Cellular and Molecular Biology
  • Materials Science

Background:

  • Cellular signals (electrophysiological, chemical, mechanical, optical) are crucial for physiological functions and cell fate.
  • High-resolution analysis of these complex signals is vital for understanding life processes, diseases, and precision medicine.
  • Traditional methods face limitations in capturing the dynamic and heterogeneous nature of cellular signals.

Purpose of the Study:

  • To review the technological foundations of integrated circuit (IC) technology for cellular signal analysis.
  • To explore multimodal sensing mechanisms and emerging applications of ICs in cellular analysis.
  • To discuss advancements in chip-level cellular analysis driven by CMOS and MEMS co-integration.

Main Methods:

  • Review of IC technologies including complementary metal-oxide-semiconductor (CMOS) and micro-electro-mechanical systems (MEMS).
  • Focus on bioelectronic interfaces, biocompatible packaging, and low-noise signal processing for sensitive signal acquisition.
  • Examination of microelectrode arrays, field-effect transistors, CMOS image sensors, MEMS sensors, and chemical sensing chips.

Main Results:

  • IC technology enables unprecedented capabilities for high-resolution spatiotemporal analysis of cellular signals.
  • Breakthroughs in sensor technologies facilitate single-cell and population-level detection of multimodal signals.
  • Applications span drug screening, clinical diagnostics, single-cell analysis, and brain-computer interfaces.

Conclusions:

  • IC-based cellular analysis represents a paradigm shift from conventional instruments and microfluidics to chip-level solutions.
  • Future directions include material innovation, 3D integration, and brain-inspired computing for enhanced cellular analysis.
  • Addressing challenges like biocompatibility and crosstalk is key to realizing the full potential of this technology.