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Updated: Jun 19, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Modular Access to Alkyl Germanes Via Ni-Catalyzed Regioselective Reductive Arylgermylation of Activated Alkenes
Xiaolin Ren1, Siyu Wan1, Yuan Huang1
1Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
Abstract:
Herein, we report a modular and practical nickel-catalyzed reductive arylgermylation of activated alkenes by employing readily available aryl/vinyl (pseudo)halides and commercial chlorogermanes. A broad range of activated alkenes with diverse functional groups are well-compatible under mild reaction conditions, delivering a series of valuable alkylgermanes in high efficiency. Notably, synthetically useful 1,1-borylgermyl compounds, which have been validated as versatile building blocks, can be efficiently assembled via this protocol, further demonstrating the synthetic utility of this method.
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