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Updated: Jun 19, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Emulsifier hydrolysis, emulsion specific surface area and stability synergistically regulate lipid release behavior
Xiang Huang1, Yihan Yang1, Yue Li1
1School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Abstract:
This study investigated the influence of different degrees of substitution (DS) octenyl succinic anhydride (OSA) starches synergistic with EGCG on emulsifier hydrolysis and lipid release behavior in emulsion. High DS OSA (H-OSA, DS = 0.053) and EGCG notably attenuated the emulsifier hydrolysis rate. Lipid release was increased in H-OSA emulsions, while decreased in low DS OSA (L-OSA, DS = 0.018). The smaller droplet size (0.19 μm) of H-OSA emulsions enlarged the specific surface area, thus accelerating lipid hydrolysis. Confocal laser scanning microscopy showed a dramatic increase in droplet size of L-OSA emulsions caused by droplet flocculation during digestion. Bile salt deficiency analysis revealed that H-OSA and EGCG enhanced lipid hydrolysis efficiency by promoting micelle formation. Calcium ion deficiency analysis suggested that H-OSA and EGCG inhibited pancreatic lipase activity and destabilized micelles, reducing the release of free fatty acids (6.71%). Furthermore, the H-OSA and EGCG maintained the emulsion stability during digestion.
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