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Fish Consumption and Colorectal Neoplasms among Lynch Syndrome Carriers.
Marjolein T Bulbaai1, Evertine Wesselink1, Tanya M Bisseling2
1Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
The Journal of Nutrition
|June 17, 2026
Summary
Total fish intake does not affect colorectal neoplasm (CRN) risk in Lynch syndrome (LS) carriers. However, increased canned fish consumption may elevate CRN risk, warranting further investigation.
Area of Science:
- Gastroenterology
- Oncology
- Nutritional Science
Background:
- Fish intake, rich in omega-3 fatty acids, may have anti-neoplastic properties.
- The impact of fish consumption on colorectal neoplasm (CRN) development in Lynch syndrome (LS) carriers is not well understood.
Purpose of the Study:
- To investigate the association between fish intake and CRN risk in LS carriers.
- To explore potential modifying factors such as NSAID/aspirin use, sex, and region.
- To analyze the impact of specific fish types on CRN risk.
Main Methods:
- Utilized data from 1,816 LS carriers across GEOLynch and Colon Cancer Family Registry cohorts.
- Assessed fish intake via food frequency questionnaires.
- Employed multivariable Cox proportional hazards models to analyze CRN risk.
Main Results:
- No significant association was found between total fish intake and CRN risk (HR 1.03; 95% CI: 0.81, 1.32).
- No association was observed for incremental increases in total fish intake (HR 1.0; 95% CI: 0.95, 1.05).
- A potential increase in CRN risk was linked to canned fish intake (HR 1.06; 95% CI: 1.01, 1.10).
Conclusions:
- Overall fish consumption does not appear to impact CRN development in individuals with LS.
- The specific role of canned fish in CRN risk requires additional research.
