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Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

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Related Experiment Video

Updated: Jun 19, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Gene therapy for aging and longevity.

Stacia P A Everts1, Michael Florea2, João Pedro de Magalhães1

  • 1Genomics of Ageing and Rejuvenation Lab, Department of Inflammation and Ageing, College of Medicine and Health, University of Birmingham, Birmingham B15 2TT, UK.

Trends in Molecular Medicine
|June 17, 2026
PubMed
Summary
This summary is machine-generated.

Gene therapy offers a promising approach to combat aging and age-related diseases by targeting fundamental aging mechanisms. This innovative strategy holds potential for extending lifespan and improving healthspan, reprogramming the aging process.

Keywords:
AAVgerosciencehealthspanlifespanrejuvenation

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Last Updated: Jun 19, 2026

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Area of Science:

  • Gerontology and Genetics
  • Biomedical Research
  • Translational Medicine

Background:

  • Aging is a universal biological process linked to major causes of death.
  • Genetic factors significantly influence lifespan and aging.
  • Translating aging research from animal models to human therapies is complex.

Purpose of the Study:

  • To review recent advances in gene therapy for aging.
  • To explore potential targets, delivery methods, and cellular rejuvenation strategies.
  • To discuss insights from long-lived species for longevity research.

Main Methods:

  • Review of current scientific literature on gene therapy and aging.
  • Analysis of genetic manipulation techniques in aging models.
  • Examination of cellular rejuvenation and longevity research.

Main Results:

  • Single-gene therapies show promise in treating age-related diseases.
  • Gene therapy can directly target core aging mechanisms.
  • Progress is being made in understanding aging through long-lived species.

Conclusions:

  • Longevity gene therapy presents a novel strategy to reprogram aging.
  • Gene therapy offers a promising path to delay age-related decline and extend healthspan.
  • Further research is needed to overcome challenges in clinical translation.