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A dermo-hypothalamic axis driven by TNF-α mediates sleep disturbances in psoriasis

Dandan Chen1,2, Ying Ma3, Jiliang Lu1

  • 1Department of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Communications Biology
|June 17, 2026
PubMed
Summary

Psoriasis causes sleep disturbances through brain inflammation, not just itching. Targeting tumor necrosis factor-alpha in the brain may treat psoriasis-related insomnia.

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