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Updated: Jun 19, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Primary anorectal melanotic melanoma: a case report
Kaitlyn Brown1, Sofia Sirocchi2, William Frank Willett3
1Philadelphia College of Osteopathic Medicine - Georgia Campus, 625 Old Peachtree Rd NW, Suwanee, GA, 30024, USA. kb2979@pcom.edu.
Journal of Medical Case Reports
|June 18, 2026
Summary
Prompt colonoscopic evaluation is crucial for early detection of rare anorectal melanoma (AM). This case highlights successful transanal resection and the need for standardized AM treatment protocols.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Dermatopathology
Background:
- Anorectal melanoma (AM) is a rare, aggressive cancer often diagnosed at advanced stages.
- Early diagnosis and prompt evaluation are critical for improving patient outcomes.
- Standardized treatment protocols for AM are currently lacking.
Purpose of the Study:
- To report a case of successful management of anorectal melanoma.
- To emphasize the importance of colonoscopy in diagnosing anorectal conditions.
- To highlight the need for further research in AM treatment.
Main Methods:
- A 71-year-old male presented with rectal bleeding.
- Colonoscopy revealed a pigmented anorectal mass.
- Diagnosis confirmed by histopathology and immunohistochemistry (S-100, HMB45, Melan-A).
- Staging via CT scan showed no metastasis.
- Patient underwent transanal resection with no residual disease.
Main Results:
- Histopathology confirmed anorectal melanoma.
- Immunohistochemistry supported the diagnosis.
- CT scan ruled out metastasis.
- Transanal resection achieved clear margins.
- Two-year follow-up showed no recurrence.
Conclusions:
- Timely recognition and diagnosis of AM are vital.
- Successful surgical management can lead to favorable outcomes.
- Further research is needed to establish optimal treatment strategies for AM.
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