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Penile Metastasis From Dedifferentiated Prostate Cancer With Low PSA Levels: A Case Report.
Xianqi Shen1, Xinwen Nian1, Bosi Zhang1
1Department of Urology Changhai Hospital Shanghai China.
Clinical Case Reports
|June 18, 2026
Summary
Penile metastasis from prostate cancer is rare but can occur even with stable prostate-specific antigen (PSA) levels. Early suspicion and diagnosis are crucial for managing this poor-prognosis condition.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Penile metastasis from prostate cancer is an infrequent occurrence.
- Management guidelines for this condition lack high-level evidence.
- Prognosis is generally poor.
Purpose of the Study:
- To report a case of penile metastasis from prostate cancer.
- To emphasize the importance of clinical suspicion in specific scenarios.
- To highlight diagnostic and therapeutic considerations.
Main Methods:
- Case report of a 68-year-old male with prostate cancer.
- Description of diagnostic workup including imaging and intraoperative pathology.
- Details of surgical intervention (total penectomy and urinary diversion).
Main Results:
- Penile metastasis was confirmed postoperatively as poorly differentiated adenocarcinoma.
- Metastasis occurred despite stable prostate-specific antigen (PSA) levels and prior treatments.
- The tumor showed morphological changes consistent with prior therapy.
Conclusions:
- Clinical suspicion for penile metastasis is vital in prostate cancer patients, even with stable PSA.
- Tumor dedifferentiation may indicate metastatic potential.
- Prompt diagnosis and intervention are essential for optimal patient outcomes.
