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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

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Association Between Cannabis Use and Tinnitus: A Multi-Center Propensity-Score-Matched Cohort Study.

Oluwatobiloba Ayo-Ajibola¹, Tyler Jung¹, Diego Gonzalves¹

¹Keck School of Medicine of the University of Southern California Los Angeles California USA.

|June 18, 2026

Summary

Cannabis use disorders (CRD) may increase the short-term risk of developing tinnitus. This risk appears higher with more severe cannabis use, but no significant long-term trends were observed.

Keywords:

THC cannabis otology tinnitus

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Area of Science:

Neuroscience
Public Health
Clinical Research

Background:

Existing research on cannabis use and tinnitus presents mixed findings.
Different patterns of cannabis consumption may influence tinnitus risk uniquely.
Cannabis-related disorders (CRD) represent a significant public health concern.

Purpose of the Study:

To investigate the association between cannabis-related disorders (CRD) and the risk of developing tinnitus.
To analyze the impact of varying levels of cannabis use intensity on tinnitus incidence.
To examine short-term (1-year) and long-term (5 and 10-year) risks.

Main Methods:

A propensity-score-matched cohort study utilizing the TriNetX multi-institutional research database.
Adult patients with CRD were matched to a control group without CRD history.
CRD patients were stratified by use, abuse, or dependence; Cox regression analyzed tinnitus outcomes.

Main Results:

Tinnitus incidence at 1, 5, and 10 years post-CRD diagnosis was 0.7%, 1.8%, and 2.1%, respectively.
A significantly higher 1-year risk of tinnitus was observed in patients with any CRD (HR=1.30).
Short-term risk increased with CRD severity: use (HR=1.30), abuse (HR=1.42), and dependence (HR=1.55).

Conclusions:

Cannabis use, particularly severe forms like dependence, may elevate the short-term risk of tinnitus.
No significant trends in tinnitus development were found at 5 and 10 years.
Further research is needed to explore dose-dependent relationships and underlying mechanisms.