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Related Experiment Video

Updated: Jun 19, 2026

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
09:49

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Published on: August 13, 2015

The Association Between Childhood Maltreatment and Adult Intestinal Disorders: A Three-Level Meta-Analysis.

Han Ding1, Shuying Chen1, Faliang Xie1

  • 1Department of Maternal, Child, and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.

Trauma, Violence & Abuse
|June 18, 2026
PubMed
Summary
This summary is machine-generated.

Childhood maltreatment (CM) significantly increases the risk of adult intestinal disorders, particularly irritable bowel syndrome. This meta-analysis confirms CM as a key factor in specific gut conditions.

Keywords:
abuseadult intestinal diseaseschildhood maltreatmentneglectthree-level meta-analysis

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Area of Science:

  • Gastroenterology
  • Psychiatry
  • Epidemiology

Background:

  • Accumulating evidence links childhood maltreatment (CM) to adult intestinal disorders, but findings are inconsistent.
  • Understanding the specific associations across different intestinal conditions and maltreatment types is crucial for etiological models.

Purpose of the Study:

  • To quantitatively synthesize existing data on the association between CM and adult intestinal disorders.
  • To assess the specificity of this association across various disease subtypes and maltreatment types.

Main Methods:

  • A three-level meta-analysis was conducted.
  • A comprehensive literature search identified 22 studies (498,709 participants) from major databases up to April 2026.
  • Pooled results and sensitivity analyses were performed to assess effect sizes and publication bias.

Main Results:

  • A significant positive association was found between CM and the risk of adult intestinal disorders (OR = 1.53).
  • Irritable bowel syndrome showed a consistent link with nearly all maltreatment types (OR range: 1.44-1.91).
  • Functional dyspepsia, inflammatory bowel disease, Crohn's disease, and ulcerative colitis did not show statistically significant associations with CM.

Conclusions:

  • Childhood maltreatment is a notable risk factor for specific adult intestinal disorders, especially irritable bowel syndrome.
  • These findings underscore the importance of integrating early-life adversity into the understanding and treatment of intestinal conditions.
  • Trauma-informed care is essential for individuals with intestinal disorders with a history of maltreatment.