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Fulminant Eosinophilic Myocarditis After Sequential Biologic Therapy in Ulcerative Colitis.
Jinyoung Lee1, Darae Kim1, David Hong1
1Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
JACC. Case Reports
|June 18, 2026
Summary
Eosinophilic myocarditis can cause severe heart failure in patients with inflammatory bowel disease on biologics. Early diagnosis via biopsy and targeted therapy, like mepolizumab, can restore heart function.
Area of Science:
- Cardiology
- Immunology
- Gastroenterology
Background:
- Eosinophilic myocarditis presents diversely and can lead to sudden cardiogenic shock.
- Patients with inflammatory bowel disease (IBD) on biologic therapies are at risk.
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