Dual MOF-engineered 3D-printed alginate-based hydrogels for enhanced wound regeneration

3D-printed MOF-modified hydrogels hold significant potential for enhancing wound healing. However, reliance on a single MOF poses limitations in achieving complete wound recovery within a constrained timeframe, highlighting the need to explore MOFs with diverse functionalities to improve healing outcomes. In this study, we developed a novel 3D printing approach to fabricate customized hydrogels incorporating dual MOFs (ZIF-8 and MIL-100 (Fe)). We also conducted a systematic investigation of the differences in wound healing performance between these MOFs. The results demonstrated that all formulations exhibit strong antibacterial activity, high water content, and excellent biocompatibility. In animal trauma models, the dual MOF (D-MOF) hydrogel achieved complete wound healing by the 14th day, due to its ability to reduce inflammation and enhance angiogenesis, as demonstrated through immunohistochemical (IHC) staining. Overall, this 3D-printed wound dressing, capable of synthesizing various MOFs in situ, offers a promising therapeutic strategy for wound repair.