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Published on: May 16, 2014

A potential role for effector T cells with Fc receptors in kidney transplant antibody-mediated rejection

Patrick T Gauthier1, Philip F Halloran2

  • 1Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada.

Kidney International
|June 18, 2026
PubMed

Antibody-mediated rejection, a leading cause of kidney transplant failure, is believed to be largely mediated by natural killer cells, with CD16a (FCGR3a) Fc receptors engaging the Fc portions of donor-specific antibodies on the graft endothelium, possibly in concert with "missing self" recognition. The paper by Vaulet et al. in this issue raises the possibility that clonally expanded effector T cells with Fc receptors may also play a role in the pathogenesis of antibody-mediated rejection.

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