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Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

Endoscopic Procedures I: Esophagogastroduodenoscopy

An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...

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Nationwide Survey on Endoscopic Submucosal Dissection for Early Gastric Cancer in Korea: Results From the Korean College of <i>Helicobacter</i> and Upper Gastrointestinal Research (KCHUGR) 2023 Survey.

Journal of gastric cancer·2026
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Nationwide Survey on Endoscopic Submucosal Dissection for Early Gastric Cancer in Korea: Results From the Korean College of Helicobacter and Upper Gastrointestinal Research (KCHUGR) 2023 Survey.

The Korean journal of helicobacter and upper gastrointestinal research·2026
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Long-term clinical outcomes of gastric mucosa-associated lymphoid tissue lymphoma: a retrospective study in regions with a high prevalence of Helicobacter pylori infection.

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Tegoprazan-Based Triple Therapy for Helicobacter pylori Eradication: A Phase III Multicenter Randomized Clinical Trial.

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Oxysterol-binding Protein-like 3 Promotes Tumor Progression by Regulating Apoptosis and Angiogenesis in Colorectal Cancer.

Cancer genomics & proteomics·2025
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Rectal Tailgut Cyst treated with Endoscopic Mucosal Resection: A Case Report and Literature Review.

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Rifasutenizol-Based Triple Therapy for the Eradication of Helicobacter pylori.

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Endoscopic Evaluation of a Gastric Mass Mimicking a Subepithelial Tumor.

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A Case of Aortoesophageal Fistula Mimicking a Subepithelial Tumor.

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A Case of Oxyntic Gland Neoplasm Incidentally Found During Upper Endoscopic Screening.

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Related Experiment Video

Updated: Jun 20, 2026

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

Risk Factors and Prophylaxis for Post-Procedural Stricture After Esophageal Endoscopic Submucosal Dissection.

Chan-Muk Im1, Je-Seong Kim1, Wan-Sik Lee2

  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

The Korean Journal of Helicobacter and Upper Gastrointestinal Research
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

Endoscopic submucosal dissection (ESD) for esophageal neoplasms can cause strictures. A large mucosal defect after ESD, especially over 75% of the circumference, is the strongest predictor of post-procedural stricture.

Keywords:
Endoscopic submucosal dissectionEsophageal neoplasmsEsophageal stenosisProphylaxisRisk factors

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An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
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An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Published on: April 17, 2020

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Last Updated: Jun 20, 2026

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
09:40

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Published on: April 17, 2020

Area of Science:

  • Gastroenterology
  • Endoscopic Surgery
  • Oncology

Background:

  • Endoscopic submucosal dissection (ESD) is a primary treatment for superficial esophageal neoplasms.
  • Post-procedural esophageal stricture is a significant complication following ESD.
  • Identifying risk factors and effective prophylaxis is crucial for improving patient outcomes.

Purpose of the Study:

  • To analyze risk factors for post-procedural stricture after esophageal ESD.
  • To evaluate the effectiveness of different prophylactic treatments.
  • To determine the strongest predictor of esophageal stricture post-ESD.

Main Methods:

  • Retrospective analysis of 128 esophageal lesions treated with ESD over 12 years.
  • Assessment of stricture development based on lesion characteristics and treatment protocols.
  • Statistical analysis including univariate and multivariate models to identify independent risk factors.

Main Results:

  • A stricture rate of 10.2% was observed across 128 lesions.
  • Lesions with >75% circumferential mucosal defect had a significantly higher stricture rate (44.0%) compared to smaller defects.
  • A >75% circumferential mucosal defect was identified as the strongest independent risk factor for stricture (adjusted odds ratio, 34.773).

Conclusions:

  • The circumferential extent of the mucosal defect post-ESD is the primary determinant of esophageal stricture risk.
  • Careful consideration of defect size is essential for risk stratification and management planning.
  • Further research into targeted prophylactic strategies for high-risk defects is warranted.