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Special Issue on Mammalian Cell Synthetic Biology

Karmella A Haynes1, Francesca Ceroni2, Elizabeth Wayne3

  • 1Wallace H. Coulter Department of Biomedical Engineering, Emory School of Medicine, Atlanta, Georgia 30332, United States.

ACS Synthetic Biology
|June 19, 2026
PubMed
Abstract

No abstract available in PubMed .

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Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...

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