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Phosphonate analogue of 2'-deoxy-5-fluorouridylic acid
Journal of Medicinal Chemistry
|January 1, 1979
Abstract:
The phosphonate analogue (6) of 2'-deoxy-5-fluorouridylic acid has been prepared via a Pfitzner--Moffatt oxidation and Witting reaction. This compound was found to inhibit thymidylate synthetase from three sources and to be cytotoxic to H.Ep.-2 cells in culture.