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Modifications of Biodentine and Their Influence on Endodontic Properties: A Scoping Review
Rumesa Batul1, Abdul Habeeb Adil2,3, Niher Tabassum Snigdha4,5
1Conservative Dentistry Unit, School of Dental Sciences, University Sains Malaysia, Health Campus, Kota Bharu, 16150, Malaysia, usm.my.
International Journal of Dentistry
|June 19, 2026
Summary
Modifications to Biodentine, a biocompatible cement used in endodontics, can improve its properties. Research shows additives enhance biological, mechanical, and physical characteristics, but standardization is needed for clinical application.
Area of Science:
- Biomaterials science
- Dental materials
- Endodontics
Background:
- Biodentine is a widely used biocompatible tricalcium cement in endodontics.
- Limitations in radiopacity and handling properties necessitate material modifications.
- Additives are explored to overcome Biodentine's inherent limitations.
Purpose of the Study:
- To map and synthesize evidence on how fillers and additives affect Biodentine's properties.
- To review the impact of modifications on biological, mechanical, and physical characteristics.
- To provide an overview of current research on Biodentine modifications in endodontics.
Main Methods:
- Scoping review following PRISMA-ScR guidelines.
- Comprehensive literature search across Scopus, PubMed, Web of Science, and Google Scholar.
- Inclusion of in vitro studies evaluating modified Biodentine; descriptive data charting.
Main Results:
- Modifications include nanoparticles, radiopacifiers, bioactive additives, and antimicrobial agents.
- Additives aim to enhance physical, mechanical, and antimicrobial properties while maintaining biocompatibility.
- Significant heterogeneity observed in modification techniques, property evaluation, and outcomes.
Conclusions:
- Biodentine modifications with additives show potential for enhancing biological, mechanical, and physical properties.
- Standardization of methodologies and identification of optimal additive concentrations are crucial.
- Further in vivo and clinical studies are needed to validate findings and guide clinical practice.
