Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of sex on setup accuracy in radiotherapy for rectal cancer: a real-World observational study.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2026
Same author

Prospective randomized-controlled trial: efficacy of 37 °C-preheated thermoplastic elastomer (TPE) bolus in postoperative radiotherapy for breast cancer patients.

Breast cancer (Tokyo, Japan)·2025
Same author

Effectiveness of personalized open-face mask combined with styrofoam fixation in radiotherapy treatment of head and neck cancers: a prospective randomized controlled trial.

Radiation oncology (London, England)·2025
Same author

Design, synthesis and <i>in vitro</i> biological evaluation of isoxazol-4-carboxa piperidyl derivatives as new anti-influenza A agents targeting virus nucleoprotein.

RSC advances·2022
Same author

[Correlation between MR diffusion weighted imaging with malignant degree of rabbit liver VX2 tumor models].

Zhonghua yi xue za zhi·2010
Same author

[Immune response in BALB/c mice immunized with BCG expressing HBV truncated C gene and preS1 gene].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·2010
Same journal

Luliconazole Potentiates Efficacy of Miltefosine Against Leishmania donovani.

Drug development research·2026
Same journal

Naphthalene-4H-Chromene Molecular Hybrids as Dual Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease.

Drug development research·2026
Same journal

Identification of Sulfonamide-Based Thiazolidine-2,4-Dione Derivatives as VEGFR-2 and Tumor-Associated hCA IX Inhibitors With Hypoxia-Targeted Anti-Colorectal Cancer Activity.

Drug development research·2026
Same journal

Identification of Quinoline Tethered Thiadiazole/Thiazole Derivatives as Potent Tyrosinase Inhibitors With Promising Anti-Toxoplasma gondii Agents: Design, Synthesis, and Computational Analysis.

Drug development research·2026
Same journal

Selenium-Containing 1,4-Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple-Negative Breast Cancer Cells.

Drug development research·2026
Same journal

A Medicinal Chemistry Perspective on Anticonvulsant Drug Design: Targets, Mechanisms, and Spiro Compounds.

Drug development research·2026
See all related articles
  1. Home
  3. Bacterial Mrna Vaccines: Programming Immunity Against Antimicrobial Resistance.
  1. Home
  3. Bacterial Mrna Vaccines: Programming Immunity Against Antimicrobial Resistance.

Related Experiment Video

Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

Bacterial mRNA Vaccines: Programming Immunity Against Antimicrobial Resistance.

Rui Liao1,2,3, Mingxing Luo2, Fating Yang2

  • 1Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing, Chongqing, China.

Drug Development Research
|June 19, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Messenger RNA (mRNA) vaccines show promise against antibiotic-resistant bacteria. Advances in antigen design and delivery systems are accelerating development for crucial bacterial vaccines.

Keywords:
antimicrobial resistancebacterial vaccinein vitro transcribed mRNAinfectious diseaseslipid nanoparticle

More Related Videos

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi
07:56

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Published on: August 18, 2010

Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus (MRSA) Infection
07:32

Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus (MRSA) Infection

Published on: September 1, 2023

Related Experiment Videos

Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi
07:56

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Published on: August 18, 2010

Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus (MRSA) Infection
07:32

Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus (MRSA) Infection

Published on: September 1, 2023

Area of Science:

  • Vaccinology
  • Microbiology
  • Biotechnology

Background:

  • Antimicrobial resistance (AMR) is a growing global health crisis.
  • Traditional vaccine development faces challenges with bacterial pathogens.
  • Messenger RNA (mRNA) technology offers a rapid and flexible platform for vaccine development.

Purpose of the Study:

  • To review recent advances in bacterial mRNA vaccine design.
  • To summarize preclinical progress against key bacterial pathogens.
  • To highlight emerging strategies for accelerating clinical translation of mRNA vaccines.

Main Methods:

  • Review of current literature on mRNA vaccine technology for bacterial infections.
  • Analysis of progress in antigen selection, mRNA engineering, and lipid nanoparticle (LNP) delivery systems.
  • Exploration of emerging strategies including AI-guided antigen discovery and synthetic biology.

    • Main Results:

    • Preclinical success has been demonstrated against Mycobacterium tuberculosis, Pseudomonas aeruginosa, and Streptococcus pneumoniae.
    • Challenges remain in bacterial antigen expression, mucosal delivery, and immune response durability.
    • Integration of AI and synthetic biology shows potential for overcoming existing barriers.

    Conclusions:

    • Bacterial mRNA vaccines are a promising strategy to combat antibiotic-resistant infections.
    • Continued innovation in antigen design, mRNA engineering, and delivery systems is crucial.
    • Emerging technologies are poised to accelerate the clinical translation of these vaccines.