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Related Concept Videos

Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

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Association between preeclampsia and reversible cerebral vasoconstriction syndrome: A case-control study.

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Identifying Missed Diagnostic Opportunities in Maternal Stroke.

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Related Experiment Video

Updated: Jun 20, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Stroke in Pregnancy.

Valerie Arias1, Ilayda Yilmaz Soylu2, Eliza C Miller2

  • 1Department of Neurology and Critical Care Medicine, University of Pittsburgh, Pittsburgh.

International Journal of Stroke : Official Journal of the International Stroke Society
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

Pregnancy triples stroke risk due to physiological changes. Understanding pregnancy-associated vasculopathy, including preeclampsia, is key for managing maternal stroke and improving outcomes.

Keywords:
Acute stroke therapyBrain Arteriovenous MalformationsCerebral hemorrhageRisk factorsStrokeTreatment

More Related Videos

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Related Experiment Videos

Last Updated: Jun 20, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Area of Science:

  • Neurology
  • Obstetrics
  • Cardiology

Background:

  • Pregnancy and postpartum physiological changes disrupt cerebrovascular homeostasis.
  • Maternal stroke, though rare, significantly increases morbidity and mortality.
  • Stroke risk is tripled during pregnancy and the postpartum period.

Purpose of the Study:

  • Review physiological changes during pregnancy that affect cerebrovascular homeostasis.
  • Discuss pregnancy-associated syndromes predisposing to stroke.
  • Provide practical considerations for managing pregnancy-related stroke.

Main Methods:

  • Literature review of physiological changes in pregnancy.
  • Analysis of pregnancy-associated syndromes and stroke mechanisms.
  • Synthesis of clinical considerations for diagnosis and management.

Main Results:

  • Pregnancy-associated stroke mechanisms are diverse, including cardioembolism, vasculopathies, and hemorrhage.
  • Hypertensive disorders of pregnancy and stroke may share mechanisms related to endothelial dysfunction and sympathetic hyperactivity.
  • Pregnancy-associated vasculopathy may represent a continuum.

Conclusions:

  • Pregnancy-associated stroke requires specialized understanding due to unique physiological changes.
  • Early recognition and management of conditions like preeclampsia are crucial.
  • Further research into shared mechanisms can guide prevention and treatment strategies.