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Updated: Jun 20, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
[Multiple papules on the thighs in an adult]
Christiane Cussigh1, Alexander Enk2, Ferdinand Toberer2
1Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Heidelberg (UKH), Ruprecht-Karls-Universität, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland. christiane.cussigh@med.uni-heidelberg.de.
Abstract:
Initial presentation of eruptive xanthogranulomas in adulthood is less common than in childhood. The pathogenesis is not yet fully understood. Isolated case reports with associations to hematological disorders have been described. Histology reveals a dermal histiocytic inflammatory infiltrate as well as multinucleated Touton giant cells. We report a case of multiple eruptive xanthogranulomas in an adult with partial spontaneous regression.
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