Recent progress in the application of CF3-imidoyl sulfoxonium ylides in transition metal-catalyzed C-H
Xiaoying Zhao1, Dulin Kong1, Hongliang Wu1
1Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development On Tropical Herbs, School of Pharmaceutical Sciences, Hainan Medical University, Haikou, 571199, China.
Abstract:
The incorporation of CF3 groups into molecules represents a significant strategy in medicinal chemistry, as this modification can profoundly enhance their biological activities. CF3-imidoyl sulfoxonium ylides (TFISYs) have emerged as versatile and stable carbene precursors, demonstrating remarkable utility as CF3-containing coupling partners for the assembly of diverse CF3-heterocycles. This review systematically summarizes recent advances in transition metal-catalyzed, directing group-assisted C-H bond activation reactions employing TFISYs as key coupling partners. The discussion is organized to provide a clear methodological classification based on the multifunctional roles of TFISYs, which can act as alkenylating reagents as well as C1, C2, and C2N1 cyclic unit. A comprehensive evaluation of substrate compatibility, reaction mechanisms, structure modification, and practical applications in functional molecule synthesis is presented.
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