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Updated: Jun 21, 2026
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Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
Published on: February 10, 2026
Kidney Outcomes After Contrast Exposure in Patients Recovering From Dialysis-Requiring Acute Kidney Injury: A Target
Li-Chun Lin1, Thomas Tao-Min Huang2, Yi-Ting Wu2
1Division of Nephrology, Department of Internal Medicine, National Taiwan University Cancer Center, Taipei, Taiwan.
Summary
Iodinated contrast media (ICM) use after recovery from dialysis-requiring acute kidney injury (AKI-D) increases risks for recurrent dialysis and persistent kidney dysfunction. Careful consideration of contrast administration is advised for these vulnerable patients.
Area of Science:
- Nephrology
- Radiology
- Public Health
Background:
- The impact of iodinated contrast media (ICM) on kidney outcomes in patients recovering from dialysis-requiring acute kidney injury (AKI-D) is not well understood.
- Patients with a history of AKI-D may remain vulnerable to further kidney insults despite apparent recovery.
Purpose of the Study:
- To evaluate the association between ICM exposure and kidney outcomes in adults recovering from AKI-D.
- To assess the risk of recurrent dialysis and persistent kidney dysfunction following ICM administration in this population.
Main Methods:
- Retrospective cohort study using Taiwan's National Health Insurance Research Database (2015-2022).
- Target trial emulation framework with inverse probability of treatment weighting (IPTW) to compare ICM-exposed and unexposed patients.
- Primary outcomes included recurrent dialysis and persistent kidney dysfunction defined by serum creatinine levels at one year post-AKI-D recovery.
Main Results:
- Among 23,263 patients recovering from AKI-D, 6.7% received ICM within 30 days of dialysis cessation.
- ICM exposure was independently associated with a higher hazard of recurrent dialysis (sHR 1.37) and persistent kidney dysfunction (sHR 1.11).
- Risk for kidney events was highest when estimated glomerular filtration rate (eGFR) was below 36 mL/min/1.73 m² in contrast-exposed patients.
Conclusions:
- ICM exposure is associated with increased risks of recurrent dialysis and persistent kidney dysfunction in adults recovering from AKI-D.
- Findings suggest continued kidney vulnerability after AKI-D recovery and support cautious use of contrast media.
- The observational nature of the study limits definitive causal inference.
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