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Related Concept Videos

Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Kendall's Tau Test01:16

Kendall's Tau Test

Kendall's tau test, also known as the Kendall rank coefficient test, is a nonparametric method for assessing association between two variables. This test is particularly useful for identifying significant correlations when the distributions of the sample and population are unknown. Developed in 1938 by the British statistician Sir Maurice George Kendall, the tau coefficient (denoted as τ) serves as a rank correlation coefficient, with values ranging from -1 to +1.
A τ value of +1 indicates that...
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...

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Related Experiment Video

Updated: Jun 21, 2026

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

Riboregulation: a non-canonical tau function.

Katherine R LeBlanc1,2,3, Randall J Eck3,4, Sarah J Benbow3,5

  • 1Molecular & Cellular Biology Graduate Program, University of Washington, Seattle, WA, 98195, USA.

Molecular Neurodegeneration
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

Tau protein, implicated in neurodegenerative diseases, binds to RNA and impacts RNA metabolism. Further research is needed to understand tau

Keywords:
Alzheimer’s diseaseRNA metabolismTauopathy

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Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
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Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
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Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

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Related Experiment Videos

Last Updated: Jun 21, 2026

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
11:26

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Tau protein is involved in microtubule stabilization.
  • Tau has been observed to bind RNA, with recent studies suggesting a higher affinity for RNA than microtubules.
  • Tau dysfunction is linked to disruptions in RNA metabolism in neurodegenerative diseases.

Purpose of the Study:

  • To review the evidence for tau's role in RNA biology.
  • To highlight tau's function as an RNA binding protein.
  • To discuss the implications of tau-RNA interactions in both physiological and disease states.

Main Methods:

  • Literature review of existing studies on tau protein and RNA interactions.
  • Analysis of research on tau's role in RNA metabolism, including splicing, translation, and RNA degradation.
  • Examination of tau aggregate formation and its impact on RNA sequestration.

Main Results:

  • Tau protein exhibits significant RNA binding capabilities.
  • Tau dysfunction disrupts critical RNA metabolic processes such as mRNA splicing and translation.
  • Tau aggregates sequester various RNA species and RNA-binding proteins, contributing to disease pathology.

Conclusions:

  • Tau is increasingly recognized as a key RNA binding protein.
  • Understanding tau's direct RNA binding is crucial for elucidating its physiological roles and disease-related functions.
  • The complex structures of tau in different disease states present challenges for fully understanding its impact on RNA regulation.