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Updated: Jun 23, 2026
![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Divergent Functionalization of 3-methyleneisoindolin-1-ones Enabled by Visible-Light Photoredox-Catalysis
Abhishek Kumar1, Akash Bisoyi1, Veera Reddy Yatham1
1School of Chemistry, Indian Institute of Science Education and Research, Thiruvananthapuram, India.
None:
We present a redox-neutral strategy for the difunctionalization and C(sp2)-H alkylation of 3-methyleneisoindolin-1-ones using alkyl NHP esters as alkyl-radical precursors under visible-light irradiation. In the presence of alcohols, this approach affords difunctionalized products, while in the presence of a base, it yields C(sp2)-H alkylation products. The protocol offers several advantages, including metal-free, mild reaction conditions, a broad substrate scope, and compatibility with late-stage modification of pharmaceutically relevant molecules. Preliminary mechanistic investigations, such as Stern-Volmer quenching experiments, support an oxidative-quenching catalytic pathway and radical-clock, and EPR studies confirm the involvement of alkyl radicals.
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