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Proliferative Periostitis: Often Overlooked Onion-Skinning.
Reed A McKinney1, Caitlyn A Menicucci2, Logan C Helquist3
1Department of Pathology, Brooke Army Medical Center, Joint Base San Antonio, Fort Sam Houston, San Antonio, TX, 78234, USA. reedamckin@gmail.com.
Head and Neck Pathology
|June 20, 2026
Summary
Proliferative periostitis, a rare bone growth, often affects children due to chronic inflammation. Recognizing its key features in imaging and tissue samples is crucial for accurate diagnosis.
Area of Science:
- Oral and Maxillofacial Radiology
- Pediatric Dentistry
- Pathology
Background:
- Proliferative periostitis, or Garré osteomyelitis, is an uncommon periosteal reaction.
- Characterized by reactive bone formation due to chronic low-grade inflammation or infection.
- Most frequently observed in pediatric patients.
Purpose of the Study:
- To describe a case of proliferative periostitis in a pediatric patient.
- To correlate clinical, radiographic, and histologic findings for diagnosis.
Main Methods:
- Case report of a 6-year-old female with cheek swelling.
- Clinical examination of swelling along the buccal aspect of tooth #30 and lateral mandible.
- Radiographic and histologic evaluation of the affected area.
Main Results:
- The patient presented with a two-week history of right cheek swelling.
- Clinical, radiographic, and histologic findings were consistent with proliferative periostitis.
- The diagnosis was confirmed through comprehensive evaluation.
Conclusions:
- Familiarity with the radiographic and histologic findings of proliferative periostitis is essential.
- Accurate diagnosis relies on integrating clinical, radiographic, and histologic data.
- Early recognition aids in appropriate management of this condition.
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