Related Experiment Video
Updated: Jun 23, 2026
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Multicomponent Betti reaction affords covalent organic framework nanoreactor for palladium-catalyzed nitroarene
Neda Salarinejad1, Mohammad Dinari2, Jonas Lins3
1Department of Chemistry, Isfahan University of Technology, Isfahan, 8415683111, Iran.
None:
Multicomponent reactions (MCRs) offer a sustainable and efficient pathway to complex molecular architectures. Here, we show the design and synthesis of a α-amino(2-hydroxybenzyl)-linked covalent organic framework (Betti-COF) via a one-pot, three-component solvothermal Betti reaction. This approach expands the scope of the MCR-based COF synthesis strategies by introducing a multicomponent pathway to highly ordered crystalline frameworks without the need for step-by-step linkage construction. The resulting s-Betti-COF exhibits a distinct hollow spherical morphology, high thermal stability, and robust porosity. This framework provides ideal support for the immobilization of small palladium nanoparticles (1-2 nm) within its pores to form the s-Betti-COF nanocomposite. The prepared samples were characterized by FT-IR, DNP-enhanced 13C CP-MAS NMR, DNP-enhanced 15N CP-MAS NMR, XRD, HR-TEM, FE-SEM, EDS, XPS, and nitrogen physisorption analysis. Kinetic investigations, including Hammett analysis, support a reaction mechanism involving an anionic intermediate. This study introduces the Betti reaction as a synthetic tool for constructing functional COFs and establishes these materials as highly effective nanoreactors for heterogeneous catalysis.
More Related Videos
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
09:08A Simple and Efficient Protocol for the Catalytic Insertion Polymerization of Functional Norbornenes
Published on: February 27, 2017
Related Concept Videos
Electrophilic Aromatic Substitution: Nitration of Benzene
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction
Pericyclic Reactions: Introduction
Pericyclic reactions can be classified into three categories: electrocyclic reactions, cycloaddition reactions, and sigmatropic rearrangements. Electrocyclic reactions and sigmatropic rearrangements are...
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
Rate-Determining Steps
In a multistep reaction mechanism, one of the elementary steps progresses significantly slower than the others. This slowest step is called the rate-limiting step (or rate-determining step). A reaction cannot proceed faster than its slowest step, and hence, the rate-determining step limits the overall reaction rate.
The concept of rate-determining step can be understood from the analogy of a 4-lane freeway with a short-stretch of traffic-bottleneck caused due to...
Preparation of Amines: Reduction of Oximes and Nitro Compounds
Though catalytic hydrogenation can reduce nitrobenzenes, the reduction is nonselective in the presence of other functional groups. For instance, if nitrobenzene contains an aldehyde group,...