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Updated: Jun 23, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
Metabolic Dysfunction-Associated Fibrosis 5 Score and the Risk of Liver-Related Events in the General Population
Byeong Geun Song1, Goeun Park2, Myung Ji Goh1
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
The metabolic dysfunction-associated fibrosis 5 (MAF-5) score effectively identifies liver fibrosis risk. An age-modified MAF-5 (aMAF-5) score further enhances prediction of liver-related events, aiding in targeted surveillance.
Area of Science:
- Hepatology
- Non-invasive biomarkers
- Fibrosis staging
Background:
- The MAF-5 tool aids in identifying individuals at high risk for liver fibrosis.
- Its capacity to predict liver-related events (LREs) requires further investigation.
Purpose of the Study:
- To evaluate the MAF-5 score's ability to predict LREs.
- To assess if modifications to the MAF-5 score can improve LRE prediction.
Main Methods:
- A retrospective cohort study of 62,625 adults.
- Calculation and comparison of MAF-5 scores with other non-invasive biomarkers.
- Development and assessment of a modified MAF-5 score (aMAF-5).
Main Results:
- The MAF-5 score stratified LRE risk into low, intermediate, and high categories.
- An age-modified MAF-5 (aMAF-5) score demonstrated improved predictive performance (C-index: 0.870).
- Modified criteria improved sensitivity and specificity for LRE prediction.
Conclusions:
- The MAF-5 score effectively stratifies LRE risk.
- The aMAF-5 score offers enhanced risk stratification for LREs.
- These tools identify individuals who may benefit from increased surveillance for LREs.
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