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Published on: November 28, 2019
Endogenous metabolite signaling orchestrates tumor immune evasion
Xiaorui Liu1, Congqing Jiang1, Youjun Li1
1Department of Colorectal and Anal Surgery, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, China.
Abstract:
Endogenous metabolites are a class of bioactive metabolic molecules synthesized endogenously within the organism that mediate core physiological processes, spanning bioactive small-molecule compounds, carbohydrates, nucleotides, and gut microbial metabolites. Serving as the fundamental basis for sustaining normal physiological homeostasis, these metabolites also exert pivotal regulatory effects within the tumor microenvironment, especially during the progression of cancer immune evasion. This review encapsulates the major classifications, biological functions, and underlying mechanisms of endogenous metabolites, with a dedicated focus on dissecting the molecular pathways through which these metabolites either facilitate or suppress tumor immune evasion. Additionally, it delves into the interplay between endogenous metabolites and immune checkpoint blockade therapy, with the ultimate goal of offering innovative research insights and promising therapeutic targets for the advancement of cancer immunotherapy.
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